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Publications

Selected Lab Publications

An, J., Ribeiro, R.C.J., Webb, P. Gustafsson, J. A., Lomri, N., Kushner,  P. J., Baxter, J. D., and D. C. Leitman.  Estradiol repression of tumor necrosis factor-a transcription requires estrogen receptor function-2 and is enhanced by coactivators. Proceedings National Academy of Sciences USA 96:15161-15166, 1999.

An, J., Tzagarakis-Foster, C. Scharschmidt, T. C., Lomri, N., and D. C. Leitman.  Estrogen receptor b selective transcriptional activity and coregulator recruitment by phytoestrogens. Journal of Biological Chemistry 276:17808-17814, 2001.

Tzagarakis-Foster, C., Geleziunas, R., Lomri, A., An, J., and D. C. Leitman. Estradiol represses human T-cell leukemia virus type I tax activation of tumor necrosis factor-a gene transcription.  Journal of Biological Chemistry 277:44772-44777, 2002.

Paruthiyil, S., Parmar,H., Kerekatte, V. Cunha,G. R., Firestone, G. L and D. C. Leitman. Estrogen receptor b inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Research, 64:423-428, 2004.

Tee, M. K., Rogatsky, I., Tzagarakis-Foster, C., Cvoro, A., An, J., Christy, R. J., Yamamoto, K. R. and D. C. Leitman. Estradiol and selective estrogen receptor modulators differentially regulate target genes by estrogen receptor a and b. Molecular Biology of the Cell, 15:1262-1272, 2004.

Cvoro, A., Tzagarakis-Foster, C., Tatomer, D., Paruthiyil, S. Fox .M and D. C. Leitman.  Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Molecular Cell 21, 555–564, 2006.

Cvoro, A., Paruthiyil, S.,Jones, J., Tzagarakis-Foster, C., Clegg, N. J., Tatomer, D., Medina, R. T. Tagliaferri, M., Schaufele, F., Scanlan, T. S., Diamond, M. I., and D. C. Leitman. Selective Activation of Estrogen Receptor b Transcriptional Pathways by an Herbal Extract Used to Treat Hot Flashes. Endocrinology 148:538-547, 2007.

Levy, N., Zhao, X.,Tang, H., Jaffe, R.B., Speed, T. P. and D. C. Leitman. Multiple transcription factor elements collaborate with ERa to mediate transcriptional activation by estradiol and SERMs. Endocrinology 148:3449-3558, 2007.

Levy, N. Tatomer, D., Herber, C.B., Zhao, X.,Tang, H., Sargeant, T, Ball, L., Summers, J., Speed, T. P. and Dale C. Leitman. Estradiol and selective estrogen receptor modulators differentially regulate native estrogen receptor regulatory elements with ERa and ERb. Molecular Endocrinology, 22:287-303, 2008.

Cvoro A, Tatomer, D., Tee M-K., Zogovic, T. Harris H. A., and D. C. Leitman. Selective Estrogen Receptor-b Agonists Repress Transcription of Proinflammatory Genes. Journal of Immunology, 180: 630–636, 2008.

Mersereau, J. E., Levy, N., Staub, R. E., Baggett, S., Zogovic, T., Chow, S., Ricke, W. A., Tagliaferri, M., Cohen, I., Bjeldanes L. F., and D. C. Leitman. Liquiritigenin is a Plant-derived Highly Selective Estrogen Receptor b Agonist. Molecular and Cellular Endocrinology, 283:49-57 2008.

Ball, L. J., Levy, N., Zhao, X., Griffin, C, Tagliaferri, M., Cohen, I., Ricke, W. A, Speed, T. P.,  Firestone, G. L. and D. C. Leitman., Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements, Molecular and Cellular Endocrinology, 299:204-11, 2009.